fahrschule haass Can Be Spaß für jedermann
fahrschule haass Can Be Spaß für jedermann
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81377 München christian.haass(at)dzne.de +49 89 4400-46549 Areas of investigation/research focus Prof. Haass started to work on Alzheimer's disease (AD) in 1990 at a time, when very little welches known about the cellular mechanisms involved. Based on the pathology, which shows invariably the accumulation and deposition of Amyloid ß-peptide (Aß), he focused his work on the generation and metabolism of Aß. Christian Haass hypothesized against the widely accepted general opinion hinein this field that Aß may be produced from its precursor rein a physiologically gewöhnlich pathway and not necessarily in a pathological process. Indeed he found by using very simple tissue culture systems that Aß is produced and liberated under physiological conditions. This pivotal finding welches a major breakthrough for the entire field, since it allowed elucidating the molecular principles behind Aß generation as well as the identification of the enzymes (the so-called secretases) involved in generation and liberation of the peptide and finally the development of selective inhibitors to therapeutically lower Aß production in patients.
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Christian Haass is a German Biochemist and known for his work on the cell biology of neurodegenerative diseases.
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Leichte vierrädrige Straßen-Quads mit einer Nenndauerleistung/Nutzleistung von nicht etliche wie 4 kW zumal vierrädrige Leichtkraftfahrzeuge mit einer Nenndauerleistung/Nutzleistung von nicht eine größere anzahl als 6 kW, jeweilig mit nicht eine größere anzahl denn zwei Sitzplätzen, einer durch die Bauart bestimmten Höchstgeschwindigkeit von nicht mehr als 45 sachen, einer maximalen Leermasse von 425 kg des weiteren einem Fremdzündungsmotor mit einem Hubraum von nicht mehr als 50 cm³ oder einem Selbstzündungsmotor mit einem Hubraum von nicht etliche wie 500 zentimeter³ oder einer anderen Antriebsform.
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Inhibition of secretases as a therapeutic approach requires detailed knowledge about the physiological functions and biochemical properties of these enzymes to avoid unwanted side effects. Christian Haass welches the first to demonstrate a physiological function for beta-secretase. He showed that this protease is critically required for the regulation of myelination. Furthermore, he identified a novel APP processing pathway, which welches overlooked for more than 20 years and which has strong implications for clinical trials using beta-secretase inhibitors. He was also the first to identify the highly complicated subunit composition of gamma-secretase. All these findings not only helped to understand several signaling pathways critically involved in brain development (such as myelination and cell differentiation) but also provided the Stützpunkt for several current therapeutic approaches.
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